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class="headerBottomLook"><span>瀏覽次數：</span><b>16</b></p></div><div id="tr3r3rj" class="newsIndex_seo_content has_imgs" ><div><img class="zhanwei"/><div id="99ddf1h" class="style_reset self_style"><p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">在中國，有超過(guò)70.3%的慢阻肺病人無(wú)癥狀，或是癥狀較少。但通過(guò)肺功能檢測就會(huì )發(fā)現，這些病人的肺功能已經(jīng)受損?！拔覀冃枰D變慢阻肺的診治觀(guān)念，對慢阻肺做到早診早治?！辩娔仙綇娬{。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><br /> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">“PM2.5濃度每上升10ug/m3，肺功能（指標）下降26毫升?！比截握f(shuō)，“這對我們今后的防治來(lái)講，除了告誡大家要戒煙，改善環(huán)境也非常重要?！?/span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><br /> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">流行病學(xué)研究顯示，我國40歲以上人群的慢阻肺的患病率達8.2%，即目前我國約有4000萬(wàn)慢阻肺患者。超過(guò)70%的慢阻肺患者屬于早期患者，而絕大部分早期慢阻肺患者未主動(dòng)尋求醫療幫助，錯過(guò)了最佳治療時(shí)間。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><br /> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">噻托溴銨作為一種長(cháng)效的抗膽堿能支氣管舒張劑，目前國內外治療指南均推薦作為慢阻肺穩定期的核心治療藥物，在臨床上已得到了廣泛應用。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><br /> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">慢性阻塞性肺疾?。ㄒ韵潞?jiǎn)稱(chēng)慢阻肺）是全球發(fā)病率和死亡率較高的疾病之一。在中國，慢阻肺已排在致命疾病的第三位。統計資料顯示，目前我國約有四千萬(wàn)慢阻肺患者。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><br /> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">2017年9月15日，在一場(chǎng)早期慢阻肺研究結果的新聞發(fā)布會(huì )上，中國工程院院士鐘南山提醒，早期慢阻肺的病人不僅在中國，包括在美國，都未得到醫生及患者本人的重視和干預。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><br /> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">一周之前的9月7日，由廣州醫科大學(xué)附屬第一醫院廣州呼吸疾病研究所、國家呼吸系統疾病臨床醫學(xué)研究中心、呼吸疾病國家重點(diǎn)實(shí)驗室牽頭，國內多家醫院參與的，針對早期慢阻肺治療的一項大型臨床研究結果在國際頂級學(xué)術(shù)刊物《新英格蘭醫學(xué)雜志》上發(fā)表。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><br /> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">該研究結果顯示，噻托溴銨治療早期慢阻肺患者能有效提高肺功能、改善生活質(zhì)量和減少急性加重，同時(shí)觀(guān)察到了肺功能下降的速率有所減緩。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><br /> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">在中國，有超過(guò)70.3%的慢阻肺病人無(wú)癥狀，或是癥狀較少。但通過(guò)肺功能檢測就會(huì )發(fā)現，這些病人的肺功能已經(jīng)受損。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><br /> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">“我們需要轉變慢阻肺的診治觀(guān)念，對慢阻肺做到早診早治?！辩娔仙綇娬{，如同高血壓和糖尿病，慢阻肺的早診早治可及早挽救慢阻肺患者的肺功能，延緩疾病進(jìn)展。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><br /> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <strong><span style="font-size:16px;">早期干預“太難做了”</span></strong> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">鐘南山和呼吸疾病國家重點(diǎn)實(shí)驗室主任冉丕鑫教授領(lǐng)銜的研究團隊經(jīng)過(guò)前期的研究發(fā)現，超過(guò)70%的慢阻肺患者屬于早期患者（GOLD1-2期），這部分患者的癥狀通常比較輕微，或者沒(méi)有出現明顯的呼吸系統癥狀，如呼吸困難。因此，絕大部分早期慢阻肺患者未主動(dòng)尋求醫療幫助，直到出現氣促、呼吸困難等明顯的癥狀時(shí)才去看醫生，但此時(shí)患者的肺功能往往已經(jīng)明顯受損，錯過(guò)了最佳治療時(shí)間。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><br /> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">2009年飛赴羅馬參加國際會(huì )議時(shí)，鐘南山提出“慢阻肺能不能像高血壓、糖尿病那樣早期進(jìn)行處理？”他的考慮是，高血壓和糖尿病患者在沒(méi)有出現癥狀就進(jìn)行處理，效果不錯。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><br /> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">“當時(shí)，很多人都同意，主席在會(huì )上也表示很贊成?！辩娔仙交貞?，但主席向與會(huì )者詢(xún)問(wèn)“有沒(méi)有人打算這樣做”時(shí)，沒(méi)人舉手，因為太難做了。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">早期患者是否愿意用藥是最大的困難?！皣庹劦竭@個(gè)（問(wèn)題）也覺(jué)得難，挨家挨戶(hù)去勸他們用藥，病人就覺(jué)得自己沒(méi)有病憑什么要用藥?！辩娔仙秸f(shuō)。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><br /> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">在國外，一些研究機構也不推薦對慢阻肺患者進(jìn)行早期篩查。美國國立心肺和血液研究所、美國國立衛生研究院（NIH）和世界衛生組織（WHO）聯(lián)合發(fā)起成立的“慢性阻塞性肺疾病全球倡議（GOLD）”，只是推薦有癥狀的病人進(jìn)行防治，并不推薦在基層進(jìn)行篩查和干預。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><br /> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">2016年5月，美國預防服務(wù)工作組（USPSTF）更新慢阻肺疾病篩查，與2008年的結論相似，USPSTF未能證實(shí)對無(wú)癥狀成人進(jìn)行慢阻肺篩查能夠切實(shí)改善其生活質(zhì)量、患病率、病死率。但同時(shí)，研究也發(fā)現，無(wú)充分證據表明篩查的不利影響。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><br /> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">“我們的結果跟他們正好相反?！痹谛侣劙l(fā)布會(huì )上，鐘南山強調，“我們非常主張在基層進(jìn)行篩查，沒(méi)有癥狀或者很少癥狀的病人也要進(jìn)行干預?！?/span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><br /> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">“全世界的認知都不夠，我們現在把基層都動(dòng)員起來(lái)了?！辩娔仙綀孕?，中國在慢阻肺的早期干預方面走在世界的前列。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><br /> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <strong><span style="font-size:16px;">和空氣污染相關(guān)？</span></strong> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">冉丕鑫指出，慢阻肺的病因與吸煙、生物燃料、空氣污染有關(guān)系。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><br /> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">在廣東湛江、廣州、韶關(guān)等地，冉丕鑫和團隊通過(guò)對人群觀(guān)察發(fā)現，以空氣中PM2.5濃度范圍小于35ug/m3作為標準，濃度在35ug/m3—75ug/m3時(shí)，危險度是35ug/m3以下的2.44倍，超過(guò)75ug/m3是35ug/m3以下的2.5倍?！癙M2.5濃度每上升10ug/m3，肺功能（指標）下降26毫升?！比截握f(shuō)，“這對我們今后的防治來(lái)講，除了告誡大家要戒煙，改善環(huán)境也非常重要?！?/span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">“慢阻肺的診斷是靠肺功能檢查，在人群中靠篩查診斷慢阻肺的成本太高。但是對于高危人群，長(cháng)期抽煙、接觸生物燃料、重度空氣污染地區的人群，有些輕微癥狀比如慢性咽炎時(shí)，應該主動(dòng)去做?！比截窝a充。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><br /> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">廣州呼吸疾病研究所副所長(cháng)鄭勁平介紹，肺功能檢查的質(zhì)量控制，在過(guò)去沒(méi)有引起大家的重視，而且檢查技術(shù)需要一定的儀器，價(jià)格也比較昂貴，用得少，現在大家認識到肺功能是呼吸系統疾病診斷的“金標準”，即需要通過(guò)肺功能檢查才能進(jìn)行下一步，“現在大家對肺功能的認識逐步提高了”。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><br /> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">對于提高肺功能的檢查，除了通過(guò)宣傳推廣，他建議，在制定一系列肺功能檢查指南的基礎上，對指南進(jìn)行推廣、普及、考核、認證以及持續的質(zhì)量監控?！胺喂δ軝z查還有可能改變我們以后對疾病的觀(guān)念甚至是政策上的調整?！?/span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><br /> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">此外，對肺功能的檢查結果進(jìn)行分析的人員需要接受培訓?！霸跊](méi)有培訓的情況下，我們希望通過(guò)呼吸疾病國家醫學(xué)臨床研究中心這樣一個(gè)平臺，把大家組織起來(lái)，成立中國肺功能的質(zhì)量控制中心，所有肺功能的數據可以通過(guò)物聯(lián)網(wǎng)聯(lián)系到各個(gè)質(zhì)量控制中心，能夠更好推廣肺功能技術(shù)、更好地進(jìn)行肺功能的質(zhì)量控制、更好地把肺功能技術(shù)應用到臨床?！编崉牌秸f(shuō)。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><br /> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <strong><span style="font-size:16px;">40歲以上患病率達8.2%，防治形勢嚴峻</span></strong> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">流行病學(xué)研究顯示，我國40歲以上人群的慢阻肺的患病率達8.2%，即目前我國約有4000萬(wàn)慢阻肺患者。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">同時(shí)，相比歐美國家常見(jiàn)的吸煙危險因素，我們國家更突出的問(wèn)題是污染，隨著(zhù)人口老齡化，空氣污染、吸煙等因素的影響，慢阻肺的患病率仍在上升，給我國慢阻肺防治形勢帶來(lái)嚴峻的挑戰。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><br /> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <strong><span style="font-size:16px;">早期患者易忽視癥狀，從而延誤病情</span></strong> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">慢阻肺是一種進(jìn)展性疾病，隨著(zhù)患者年齡的增長(cháng)，肺功能逐漸下降，病情惡化。鐘南山院士和冉丕鑫教授領(lǐng)銜的研究團隊經(jīng)過(guò)前期的研究發(fā)現，超過(guò)70%的慢阻肺患者屬于早期患者，這部分患者的癥狀通常比較輕微，或者沒(méi)有出現明顯的呼吸系統癥狀，如呼吸困難。因而絕大部分早期慢阻肺患者未主動(dòng)尋求醫療幫助，直到出現氣促、呼吸困難等明顯的癥狀時(shí)才去看醫生，但此時(shí)患者的肺功能往往已經(jīng)明顯受損，錯過(guò)了最佳治療時(shí)間。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><br /> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">晚期慢阻肺患者的治療效果較差，死亡率、再住院率和致殘率都很高，給患者家庭和社會(huì )帶來(lái)了沉重的負擔。這就是當今世界慢阻肺患者治療效果較差的原因。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">而且，慢阻肺患者的早期肺功能下降更為迅速，若能找到有效的方法對早期的慢阻肺患者進(jìn)行干預，不僅可以及時(shí)防止肺功能的快速減退，還可以減緩疾病的進(jìn)展速度，減少疾病發(fā)展至晚期給患者、家庭和社會(huì )帶來(lái)的巨大痛苦和負擔。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">因此，廣州呼吸疾病研究所、呼吸疾病國家重點(diǎn)實(shí)驗室鐘南山院士和冉丕鑫教授領(lǐng)銜的團隊近年來(lái)一直呼吁應該開(kāi)展慢阻肺早期干預的研究，為提高慢阻肺的防治效果提供新的策略。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><br /> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <strong><span style="font-size:16px;">Tie-COPD的臨床啟示——早期治療的重要性</span></strong> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">該研究結果顯示，藥物治療早期慢阻肺患者能有效提高肺功能、改善生活質(zhì)量和減少急性加重，同時(shí)觀(guān)察到了肺功能下降的速率有所減緩。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">Tie-COPD（全球首個(gè)大型噻托溴銨治療早期慢阻肺臨床研究）是針對早期沒(méi)有癥狀或僅有輕微癥狀的慢阻肺患者進(jìn)行用藥干預的研究，由廣州醫科大學(xué)附屬第一醫院呼吸疾病研究所牽頭、國內多家醫院共同參與。該研究的主要研究者之一、廣州呼吸疾病研究所周玉民教授介紹說(shuō)，該研究的許多患者是通過(guò)社區篩查入選的，因為早期慢阻肺患者很少到醫院就醫。研究選擇目前慢阻肺治療的主流治療藥物長(cháng)效支氣管舒張劑----噻托溴銨（（思力華吸樂(lè )，勃林格殷格翰公司）作為研究藥物，安慰劑作為對照組，觀(guān)察了治療2年期間患者肺功能的變化，以及生活質(zhì)量、急性加重、安全性等。研究結果發(fā)現，噻托溴銨治療能有效改善患者的肺功能、提高患者生活質(zhì)量，并能降低急性加重的風(fēng)險。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">噻托溴銨作為一種長(cháng)效的抗膽堿能支氣管舒張劑，目前國內外治療指南均推薦作為慢阻肺穩定期的核心治療藥物，在臨床上已得到了廣泛應用。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">鐘南山院士指出，該研究結果對于早期慢阻肺的診治具有重要的意義，證明了在癥狀相對較少的早期慢阻肺患者，使用長(cháng)效支氣管舒張劑----噻托溴銨，能給患者帶來(lái)顯著(zhù)的臨床獲益。這給慢阻肺的治療提供了十分有價(jià)值的啟示，我們需要轉變慢阻肺的診治觀(guān)念，對慢阻肺做到“早診早治”，就像早期治療高血壓和糖尿病那樣，從而及早地挽救慢阻肺患者的肺功能，延緩疾病進(jìn)展。</span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;">而對于如何做到早診早治，鐘南山院士也提出了建議。對公眾來(lái)說(shuō)，對于長(cháng)期吸煙，反復出現咳嗽、咳痰、氣喘的人群，應當立即到正規醫院就診，做肺功能檢查，爭取盡早明確診斷并開(kāi)始治療，切莫錯過(guò)最佳治療時(shí)間。</span> </p> <p style="text-align:center;margin-top:0px;margin-bottom:0px;padding:0px;color:#404040;font-family:"Microsoft YaHei";font-size:14px;white-space:normal;"> <span style="font-size:16px;"><img src="https://img01.71360.com/file/read/www/M00/28/A4/rBwBHmSrcHaAJTwRAATGo3Gm3zo344.gif" width="750" 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